Does Use of CBD-Hemp Oil Result in a Positive Drug Test for THC or Cannabis?

[headline]A consumer who uses a high-quality, scientifically vetted hemp-based product at the standard serving size is highly unlikely to test positive for THC[/headline]

Whether you agree with it in principle or not, testing for illicit drug use is a reality for many workers in the United States. Drug testing is mandatory for federal employees, and although it isn’t required in the private sector, more employers are implementing some kind(s) of drug screening.

When drug testing is mandated, employers almost always follow the SAMHSA (Substance Abuse and Mental Health Services Administration) guidelines because it puts them on solid legal ground. Typically, there is an overlap between testing guidelines and accepted cutoff levels for drugs and drug metabolites in confirmatory testing and screening.

[quote]Keep in mind that most of the high-quality, reliable CBD-rich hemp oil products contain much less THC than cannabis. [/quote]Because THC is widely recognized as being responsible for cannabis’ psychoactivity and euphoria, a routine urine drug screen for cannabis use consists of an immunoassay with antibodies that are made to detect it, and its main metabolite, 11-nor-delta9-caboxy-THC (THC-COOH). SAMHSA has set the cutoff level for a positive urine screen in the immunoassay at 50 ng/mL. When the immunoassay screen is positive at the > 50 ng/mL level, a confirmatory GC/MS (Gas Chromatography/Mass Spectrometry) test is performed to verify the positive urine screen. The confirmatory GC/MS has a cutoff level of 15 ng/mL and is specific only to the 11-nor-THC-COOH metabolite.  

Fortunately, the urine drug screen for THC-COOH is known to have very little cross-reactivity to other cannabinoids that are not psychoactive, such as CBD (cannabidiol), CBG (cannabigerol), CBN (cannabinol), and others. This is good news for “normal” consumers of CBD/hemp oil.

That said, individuals using unusually large doses of a cannabinoid-rich hemp oil product (above 1000-2000 mg of hemp oil daily) could theoretically test positive during the initial urinary screen. Although very rare, the urine screen in these cases would likely represent a “false positive” due to other non-THC metabolites or compounds, which may cross-react with the immunoassay. When this is the case, the confirmatory GC/MS test would be negative, since CBD and other cannabinoids will not be detected by the more accurate (and specific) GC/MS screen.

Keep in mind that most of the high-quality, reliable CBD-rich hemp oil products contain much less THC than cannabis. For example, hemp contains anywhere from 1/10th to 1/300th of the THC concentration found in cannabis. An individual consuming 1000-2000 mg per day of hemp oil would thus consume approximately 3-6 mg of THC. This exceedingly high dose may result in detection of positive urine screen in up to 11% to 23% of assays. 

On the other hand, there is some data demonstrating that at daily doses of 0.5mg of THC from 3-5 servings of most commercial CBD-rich hemp oil products, the positive urine screen rate is < 0.2%. Again, most servings of typical high-quality, high-purity CBD-based hemp oil products contain well below 0.1mg of THC and therefore have over 400-600 times less THC than cannabis products. 

What does all this mean? Put simply, a consumer who uses a high-quality, scientifically vetted hemp-based product at the standard serving size is highly unlikely to test positive for THC and/or THC-COOH. However, it’s important to be cognizant that extremely high doses may result in a positive urine screen (that would be subsequently shown to be false via GC/MS). Ultimately, consumers need to be fully informed of the specific regulations posed by their employers and adjust their consumption of cannabinoid products accordingly.

[infobox] Additionally

Most research suggests that for infrequent or ‘non-daily’ users of cannabis, a typical high-dose cannabis cigarette (containing about 40mg to 50mg of THC) would result in a positive THC metabolite screen for up to 2 days at this cutoff level.  However, for routine and regular users of cannabis, this same screen could be positive for weeks, but this depends on many factors including, but not limited to:

• how much and how often cannabis is used
• the metabolism of individual being tested
• the route of administration
• other factors such as medications used, liver or kidney disease, etc.

This article is based on SAMHSA standards in the United States. Other organizations’ drug testing standards may be different, the disclosures presented in this article may vary.[/infobox]

This article is sponsored by CV Sciences, one of the leading suppliers of agricultural hemp derived CBD from seed to finished products.

References:

• Gustafson RA, Kim I, Stout PR, Klette KL, George MP, Moolchan ET, Levine B, Huestis MA. Urinary pharmacokinetics of 11-nor-9-carboxy-delta9-tetrahydrocannabinol after controlled oral delta9-tetrahydrocannabinol administration. J Anal Toxicol. 2004 Apr; 28(3):160-7
• Gustafson RA, Levine B, Stout PR, Klette KL, George MP, Moolchan ET, Huestis MA. Urinary cannabinoid detection times after controlled oral administration of delta9-tetrahydrocannabinol to humans. Clin Chem. 2003 Jul; 49(7):1114-24. 
• Kemp PM, Abukhalaf IK, Manno JE, Manno BR, Alford DD, Abusada GA. Cannabinoids in humans. I. Analysis of delta 9-tetrahydrocannabinol and six metabolites in plasma and urine using GC-MS. J Anal Toxicol. 1995 Sep; 19(5):285-91.
• Huestis MA, Mitchell JM, Cone EJ. Urinary excretion profiles of 11-nor-9-carboxy-delta 9-tetrahydrocannabinol in humans after single smoked doses of marijuana. J Anal Toxicol. 1996 Oct;20(6):441-52.
• Wall ME, Perez-Reyes M. J Clin Pharmacol. The metabolism of delta 9-tetrahydrocannabinol and related cannabinoids in man. 1981 Aug-Sep; 21(8-9 Suppl):178S-189S.

Disclaimer: The information provided in this column is intended for educational and informational purposes only. CV Sciences is not engaged in rendering legal or medical advice, and any information provided is not a substitute for professional legal or medical opinion. If you have any concern about testing positive for THC when using CBD-containing hemp oil, please seek advice from your health care professional.